New standard of care for stage 3 MSI high colon cancer - adjuvant atezolizumab/FOLFOX #asco25

GI non-CRC oral abstracts at #asco25 is 🔥. A few things: 1️⃣Dr Saeed had excellent summary of the GE/gastric studies 2️⃣PAXG (Abraxane, cisplatin, capecitabine, gemcitabine) superior to FOLFIRINOX for borderline and resectable PDAC 3️⃣TTFields positive in LA-PDAC vs gem/Abrax with 2 mo OS advantage

Early morning CSC session at #asco25 about multi-cancer detection testing which was excellent! The discussant hit all the conclusions well - low sensitivity and need for a randomized trial before can be taking to clinic are the key points

Not in Chicago but getting the updates - #ASCO25 learnings today: 😀there's an option in BRAFV600 mCRC 😀Ipi+Nivo better in MSI-h unresectable mCRC 🫤ctDNA+ still not guiding care in CC 😳CRS+HIPEC no better with chemo @oncbrothers.bsky.social got the details 👉🏻 tinyurl.com/bd75xjw7 #OncSky #MedSky

Congratulations to Alaska for passing into law bill SB15 which requires posting signs at point of sale for alcohol about the carcinogenic effects of alcohol for colon and breast cancer. (This is a first in the U.S.!) I am honored to have been able to testify on behalf of Rep Andrew Gray’s bill.

Join me tonight fir this Medscape event about alcohol and cancer register.gotowebinar.com/register/300...

New UW publication in Cancer Medicine - NCDB analysis of rectal cancer incidence/outcomes in Native Americans showing earlier onset and worse survival arguing for the critical importance of early CRC screening and target education outreach in this population onlinelibrary.wiley.com/doi/10.1002/...

Sharing this good review I just read of Triple M Overlap Syndrome (TMOS) - rare but serious complication of oncology immunotherapy with myositis, myasthenia gravis and myocarditis pubmed.ncbi.nlm.nih.gov/39897316/ #oncology #immunotherapy

New publication of the Million Women Study showing benefit of milk on incidence colorectal cancer (felt to be related to dietary calcium) and further showing alcohol and red meat are adversely associated with CRC development www.nature.com/articles/s41...

New study by Burlile J et al from Mayo defining magnitude of harm to musicianship and performance by breast cancer treatment. Chemo was most harmful for endurance, accuracy, speed ascopubs.org/doi/pdf/10.1...

STARTER-NET/JCOG1901 trial lanreotide +/- everolimus in 1L non-secretory poor prognosis GEP-NET (Ki67 5-20% or diffuse liver mets) was interesting. Big increase in PFS but no change in overall survival+ more toxicity would suggest sequential use is still ok #GI25 meetings.asco.org/abstracts-pr...

This is an absolutely outstanding article about how to make the most out of academic conferences. Many tips for @ascocancer.bsky.social meeting attendees. (Not just first time ones either!) www.chronicle.com/article/how-...

My perspective about the Surgeon General’s advisory about alcohol and cancer is included on this page, for those who are interested www.healio.com/news/hematol...

Oncologists can fully get behind this - glad the Surgeon General is pushing an important conversation forward! www.nytimes.com/2025/01/03/h...

Important JCO editorial about phase 1 and 2 trial design and the peril of using fitness for FDA filing as the primary goal, with the development of ONC201 as the example ascopubs.org/doi/full/10....

Oncology leadership everywhere: please take note

Oncology appt: Onc: Your CT scan is clear Me: It must be nice to have a good news appointment Onc: it really is Me: Oh, and I've lost weight. Onc: What? *panics* Me: Sorry, sorry, on purpose. I have lost weight on purpose. Onc: *visibly relaxes* How to freak an oncologist out 🤪 #cansky

Last week the UW Carbone Community Outreach and Engagement team got to present at UW extension conference about our lay abstract project where we try to get our science out into lay audiences (examples here cancer.wisc.edu/resources-fo...). Trying to make one for each national presentation to start

Thinking about how I wish we could suspend all bad news in the oncology clinic on the weeks of major holidays or life events