Zhongyue (John) Yang
@mutexazjy.bsky.social
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AP of Chemistry @Vanderbilt. Emphasize physics-guided protein engineering.
Things tend to slow down in winter, but Elsa Ding and Yaoyukun Jiang from our group have engineered a 'cold-adapted' version of a mesophilic amylase. Even with a 45-degree temperature drop, we still observe 30% activity.
onlinelibrary.wiley.com/doi/10.1002/...
@angewandtechemie.bsky.social
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Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering
This work uncovers molecular determinants of cold adaptation in bidomain amylases by combining MD simulations and biochemical assays, revealing that increased domain separation drives enhanced activi...
https://onlinelibrary.wiley.com/doi/10.1002/anie.202505991
8 months ago
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Physics-based modeling is key to unlocking the full potential of enzyme engineering!
add a skeleton here at some point
9 months ago
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you reached the end!!
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