We’re adding lay summaries of recent MAGIC conference presentations to our website to make our work more accessible to the neuromuscular community. These short overviews share the key ideas, aims and insights behind the science across the network. Check them out: magic-horizon.eu/project-reso...

AAV gene therapies can only progress if we can manufacture high‑quality vectors at scale. MAGIC and DINAMIQS have been working to make AAV production more robust and development‑ready, helping ensure emerging neuromuscular therapies have a practical path toward the clinic. #GeneTherapy #AAV

For #RareDiseaseDay we're highlighting the importance of equity in rare disease research and care. MAGIC partners have shared what motivates their work and how they hope to help create a fairer future. Read their words here: magic-horizon.eu/news/rare-di...

This year's JP Morgan Conference highlighted a growing focus on smart manufacturing choices in CGT. MAGIC members DiNAMIQS met with teams to discuss how strong science can be turned into scalable therapies—supporting MAGIC’s mission to advance treatments for rare neuromuscular conditions.

🧬 The past year has seen huge progress across MAGIC — from refining 3D muscle constructs to expanding engineered tissue and multi‑organoid platforms. These advances are giving us more predictive ex vivo models and helping accelerate the path toward next‑gen gene therapies. #MAGICProject

Great to see the MAGIC consortium highlighted in UCL’s story on accelerating therapies for rare neuromuscular disorders. Collaboration across Europe is essential to driving the breakthroughs patients need. 🌍✨ #MAGICconsortium #RareDisease #NeuromuscularResearch

Earlier this month, MAGIC members took part in the ESGCT Academy. PhD students presented projects linked to MAGIC and received feedback and career advice. The event also showed the depth of our expertise, with speakers supporting the next generation of researchers. #genetherapy #research

Where is MAGIC? Across Europe and beyond. Our consortium spans 10 countries, connecting leading institutions to tackle neuromuscular research challenges together. 🔗 magic-horizon.eu #MAGICProject #ResearchCollaboration #NeuromuscularResearch

ICYMI: What’s next for neuromuscular treatment development? MAGIC Project joined Muscular Dystrophy UK's Muscles Matter podcast to discuss SMA gene therapies, AI, and the future of collaborative research. 🎧 Listen: bit.ly/4aJpPodcast #MAGICProject #GeneTherapy #Podcast

🎆 Happy New Year from the MAGIC Project! 🎆 In 2026, we’ll keep pushing boundaries in neuromuscular research: ✅ Better disease models ✅ Gene therapy innovation ✅ Stronger networks for translation Learn more: magic-horizon.eu #MAGICProject #HappyNewYear

Recent advances have changed the landscape, but what’s next for neuromuscular treatment development? MAGIC joins Muscular Dystrophy UK's Muscles Matter podcast to discuss progress, research priorities & the role of AI. 🎧 Listen: www.musculardystrophyuk.org/support/serv...

Explaining gene therapy isn’t easy – but it’s essential. Francesco Saverio Tedesco from the MAGIC project shares a clear way to make it understandable for patients. Learn more about MAGIC’s patient-centred approach: magic-horizon.eu/about/object... #GeneTherapy #MAGICHorizon

Missed our latest newsletter? It was a BIG one including conference highlights, progress and our general assembly! Stay in the loop: 🔗 Sign up today ➡️ magic-horizon.eu/news-events/newsletter

🔬 Curious about the latest progress in gene therapy for muscular dystrophies? The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community. 🧬 Explore open-access papers, abstracts, and key findings here: 👉 magic-horizon.eu

Last month, MAGIC partners met in Lisbon for our annual General Assembly at GIMM. Discussions focused on: • Improving AAV delivery for gene therapy • Gene editing beyond mutation correction • 3D muscle models to accelerate testing Read more: magic-horizon.eu/news/magic-g...

✨ What is MAGIC and why does it matter for gene therapy? PI @SaverioTedesco shares how this multi-partner project tackles key challenges in rare neuromuscular conditions – building building tools for safer, more effective treatments. 🎥 Watch below #GeneTherapy #RareDisease

What’s next for gene therapy? Our workshop brought researchers together for a Q&A with MAGIC experts Eduard Ayuso, David-Alexandre Gross, Gabriela Silve & Odile Boespflug-Tanguy. From delivery challenges to emerging tech, the future looks bold. #GeneTherapy

🚨 MAGIC Project General Assembly! 🚨 Consortium partners are gathering to: ✅ Share progress ✅ Strengthen collaboration ✅ Align on next steps We’re driving innovation in neuromuscular disease & gene therapy – and building momentum for the year ahead. 🚀 #ResearchProgress

Proud to host today’s MAGIC Project workshop in Lisbon, where experts are discussing: 🔬Muscle on a Chip 🧬Gene Editing 💉Viral Transduction 🧫Vector Production We're sharing knowledge with the wider research community to accelerate progress in #genetherapy.

🔬 Earlier this month at #ESGCT2025, MAGIC partners @crick.ac.uk shared 3 posters on human models for neuromuscular gene therapy: 🧪 3D cultures for DMD 🧠 AAV dynamics in multi-organoids 🧬 Myotubular myopathy modelling Pushing boundaries in patient-relevant research. #genetherapy #MagicProject

🔬 MAGIC at #ESGCT2025! DINAMIQS shared how mass photometry boosts AAV packaging efficiency & stability. 📌 >95% full capsids = better stress resilience. 🚀 Fast, label-free AAV quality checks = smarter upstream optimisation. #MAGICProject #GeneTherapy #AAV

Great to see Francesco Saverio Tedesco presenting the latest results from the MAGIC project at #WMS2025 in Vienna this morning. Fantastic to see this international collaboration represented on the global stage 🌍🧬 #genetherapy #3Dmusclemodels

Are you attending #WMS2025 or #ESGCT2025 this week? 🔬 Make sure you check out the presentations from MAGIC members to learn more about the project and how we’re aiming to accelerate the development of gene therapies for rare neuromuscular conditions. 🧵⬇️

Headed to #WMS2025 or #ESGCT2025 next week? 🧬✈️ Members from MAGIC will be attending both – keep an eye out for posters and presentations to learn more about the project. We’re looking forward to connecting with researchers, clinicians, and collaborators across both events! 🤝

In the MAGIC project, we’re building modular 3D muscle models for conditions like FSHD, Duchenne & congenital myopathies. 🧬 Tailored cell sources 🧱 Custom matrix design 📊 Relevant functional readouts All within a scalable, reproducible platform. 🔗 magic-horizon.eu

Rare neuromuscular diseases demand global collaboration. 🌍 The MAGIC project unites researchers worldwide to advance next-gen genetic therapies. Our project leaflets, now in 6 languages, outline our goals and translational potential. 📄 Download: magic-horizon.eu/media/leafle... #RareDisease

We’re building next-gen 3D muscle models in the MAGIC Project 🧬 🔬 Patient-derived cells 💧 Microfluidics 🧫 3D tissue architecture Designed to better predict how gene therapies will work in rare neuromuscular diseases. 🔗 magic-horizon.eu #GeneTherapy

🔬 Curious about the latest progress in gene therapy for muscular dystrophies? The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community. 🧬 Explore open-access papers, abstracts, and key findings here: 👉 magic-horizon.eu #GeneTherapy #RareDisease

🚨 New publication from the #MAGICproject! A novel iPSC line from a UCMD patient with a COL6A1 mutation offers a valuable new model for studying collagen VI-related muscular dystrophies and testing therapies. 📖 Read the paper: www.sciencedirect.com/science/arti...

Developing gene therapies for rare muscular dystrophies comes with big challenges: 🔬 Lack of realistic muscle models 🧫 Targeted delivery without triggering immune responses Mariam Zhouhair (‪@crick.ac.uk) shares how the MAGIC project is tackling these. 🔗 magic-horizon.eu/news/meet-cr...

📫 Our next newsletter is landing in inboxes soon! Subscribe to hear about the latest developments from the #MAGICproject: 🔬 Genetic therapies advances for muscular dystrophies 📰 Conference & event highlights 📝 New research publications …& more! 👉 magic-horizon.eu/news-events/...

🔬 Curious about the latest progress in gene therapy for muscular dystrophies? The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community. 🧬 Explore open-access papers, abstracts, and key findings here: 👉 magic-horizon.eu #GeneTherapy #RareDisease

🚨 New pre-print from the #MAGICproject! Our team modelled L-CMD, a severe laminopathy, using iPSC-derived skeletal muscle & showed how precise CRISPR correction reverses nuclear defects, while exon-skipping doesn’t. biorxiv.org/content/10.1... #Laminopathy #GeneTherapy #iPSC

🚨 New pre-print from the #MAGICproject! We model L-CMD-a severe laminopathy-using iPSC-derived skeletal muscle & show how precise CRISPR correction reverses nuclear defects, while exon-skipping doesn’t. www.biorxiv.org/content/10.1... #Laminopathy #GeneTherapy #iPSC

🔬 In the #MAGICproject, Prof. Karen English (@muresearch.bsky.social) is tackling immune reactions to AAV gene therapies for muscular dystrophy. The goal: identify & calm early immune responses to boost safety & efficacy. 🔬 Full interview: magic-horizon.eu/news/meet-nu... #GeneTherapy #AAV

🚨 New publication from the #MAGICproject! A novel iPSC line from a UCMD patient with a COL6A1 mutation offers a valuable new model for studying collagen VI-related muscular dystrophies and testing therapies. 📖 Read the paper: www.sciencedirect.com/science/arti...

📫 Our next newsletter is landing in inboxes soon! Subscribe to hear the latest updates from the #MAGICproject, such as: 🔬 Advances in genetic therapies for muscular dystrophies 📰 Conference and event highlights 📝 New research publications …and more! 👉 Sign up: magic-horizon.eu/news-events/...

From discovery to delivery, gene therapies must be scalable. Siegfried DINAMIQS supports the #MAGICproject to tackle manufacturing early. Eduard Ayuso: “...make groundbreaking therapies manufacturable at quality and cost for patients.” 🔗 magic-horizon.eu/news/meet-di...

Rare muscular dystrophies know no borders🌍 The #MAGICproject unites global researchers to develop genetic therapies. Its now easier to learn about MAGIC's goals as our project leaflets are available in 6 languages! Download 👉 magic-horizon.eu/media/leafle... #MuscularDystrophy

🔬 Meet the minds behind MAGIC! Dive into our partner interviews to see how global experts are uniting to revolutionize gene therapies for muscular dystrophies. Discover their stories and insights here: magic-horizon.eu/news-events/... #MAGICproject #GeneTherapy #MuscularDystrophy

💫 The #MAGICProject is developing transformative gene therapies for people living with rare muscular dystrophies - conditions that affect movement, eating, breathing & more. 🧬 With leading experts on board, we’re pushing research forward, faster. 🔗 magic-horizon.eu

🎙️ “Our goal is to develop muscle models that truly reflect human disease – and use them to fast-track gene therapy testing.” – @FRelaix, UPEC In our latest #MAGIC spotlight, see how his team is advancing #MuscularDystrophy therapies. 👉 magic-horizon.eu/news/meet-up... #GeneTherapy

MAGIC aims to develop effective treatments for people living with rare muscular dystrophies. These rare conditions affect the muscles and can impact walking, eating, sleeping and breathing. Bringing together leading experts we will push research forwards, faster.🧑‍🔬 #musculardystrophy #genetherapy