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4/and a reduced capacity to activate cytotoxic T cells.

3/Strikingly, we found resistance-associated mutations in SEC24C and SEC24D in 3 patients. Melanoma cells engineered to express the SEC24C mutations observed in patients exhibit diminished STING signaling, including decreased Type I interferon production, antigen presentation

2/Over several years, we collected matched pre-treatment and post-resistance tumor biopsies in patients with metastatic melanoma who exhibited heterogeneous ICI responses to nominate additional mediators of acquired resistance.

1/Although some patients with metastatic melanoma experience durable responses to immune checkpoint inhibitors, most exhibit intrinsic or acquired resistance to these therapies.

Our paper on a new mechanism of resistance to immunotherapy in melanoma is now in print @Cancer_Cell with the @vanallenlab.bsky.social t.co/TCC4brc6yb