One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...

please come see my poster today 🥺🥺🥺 #smbe2025

new preprint from me! did you know that psi index is a hyperbolic tangent of the difference in drift between the two populations?

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

How is functional variation at large-effect loci maintained in natural populations? Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n www.biorxiv.org/content/10.1...

really happy to have participated in this project! this figure proves that a chromosome-scale sweep happened based on the time series of allele frequencies during the sweep (and even shows loci which have potentially swept independently).

new photo posts!! www.lappo.photo

did you ever need to run many SLiM simulations to understand the behavior of some popgen quantity? i have released a rust-based wrapper for SLiM that takes care of large-scale parallel runs over parameter grids! github.com/EgorLappo/sl... 1/

Thrilled to share a new lab pre-print from graduate student Tris Dodge! Tris & co elegantly uncover the genetic underpinnings and fitness consequences of a sexual mimicry polymorphism in Xiphophorus birchmanni: www.biorxiv.org/content/10.1...

hanging out at #tagc2024

It's conference application season! We in the Rosenberg Lab recently assembled a list of conferences and I thought it could be helpful for other folks doing theoretical population biology. List is below -- feel free to add any we missed!

my work on cultural evolution and transmission biases in chess is out today in Proceedings B! royalsocietypublishing.org/doi/10.1098/... humsci.stanford.edu/feature/stud...

i've been slacking off reading about phylogenetic networks and f-statistics, and instead posted some film photos from my trip to Melbourne egorlappo.me/posts/2023-0...

It seems to me that the time is ripe for a Bluesky thread about how—and maybe even why—to befriend crows. (1/n)

decided to start posting some of my film photos online! check them out here https://egorlappo.me/posts/2023-08-12-old-photos.html