Pre-print on cardiomyocyte response to novel anti-cancer drug CX-5461 now published! Includes new gene expression response data at higher CX doses. Response to micromolar CX doses starts to mimic DOX responses, suggesting that off-target effects on the heart should be considered for this drug.

Our latest work led by MD/PhD student Omar: ‘Conserved RNA-protein modules link early anthracycline responses to atrial fibrillation risk’. [1/6] www.biorxiv.org/content/10.6...

Happy to share graduate student Emma’s first paper: ‘Progressive suppression of DNA repair genes with persistent p53 activation in Doxorubicin-treated cardiomyocytes’. [1/6] www.biorxiv.org/content/10.6...

We're hiring for multiple open rank positions in the broad areas of biochemistry, molecular biology, and computational biology. With the recruitment of a new chair our Departmental strengths now include nuclear architecture, genomics and ancient DNA. jobs.sciencecareers.org/job/676677/b...

To showcase science you’re interested in seeing at ASHG26 in Montreal, submit a proposal for a Featured Symposium. Deadline is Jan 20th. Topics of interest include ‘evolutionary approaches to biological and clinical insights from phylogeny or recent human/primate lineages'.

Our preprint on chromatin accessibility changes in response to DNA-damaging agents in cardiomyocytes is now published. Congrats to Renee et al and two first time co-authors! [1/3] journals.plos.org/plosgenetics...

Happy to be at ASHG! 2 students in the lab will present posters on gene regulatory evolution in primates on Thurs: Emma focuses on responses to stimuli: 9109T John focuses on transposable elements: 6036T Please stop by if interested #ASHG25

Project led by Sayan investigating the effects of CX-5461, an anti-cancer drug currently in clinical trials, on cardiomyocytes: ‘Topoisomerase II inhibitors CX-5461 and Doxorubicin differ in their cardiotoxicity profiles.’ [1/4] www.biorxiv.org/content/10.1...

Happy to share our work led by Renee: ‘Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci.’ www.biorxiv.org/content/10.1...

Happy to share the published version of Omar & Sayan’s paper. We generated a DNA-damage-associated cardiomyocyte protein co-expression network to gain insights into tolerance to genetic variation and disease. www.sciencedirect.com/science/arti...

Come join us at #ASHG25 in Boston Oct 14-18! Abstract submission site (ashg.org/submit) is now live. Abstracts due June 9th.