biology is often plagued with irreducible latencies. accelerating progress then requires increasing bandwidth, parallelizing many experiments. prior generations optimized discoveries/hypothesis tested with elegant, serial iteration. ours will optimize discoveries/unit time.

we're entering a new phase @newlimitbio.bsky.social & beginning to progress our first medicines for aging & disease. now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life. it's a privilege to build this future with generational partners.

health is both the most valuable commodity & a Jevons good. the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.

AI2's paper finder is one of the best improvements to my research workflow in years highly recommended:

each year @newlimitbio.bsky.social, we share an update on our progress with the public this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon. watch here: m.youtube.com/watch?v=HR0-...

early winter @newlimitbio.bsky.social: - +3 TF sets with efficacy in animal disease models - +3 TF sets that restore youthful function in old T cells - 20X increase in humanized liver screening throughput - 2X better in silico reprogramming than the best baseline details: bit.ly/4iuBvqC

cognitive drills are substantially underrated in molecular biology & genomics half of creativity is having the ingredients for invention top of mind building a Borgesian mental library of enzymes & reactions pays dividends

2024 @newlimitbio.bsky.social: - 10X Engine throughput - Discovered TF sets that reprogram cell age & preserve type - Restored youthful function in a disease model with drug-like reprogramming we demonstrated that reprogramming medicines are possible 2025: we start to develop them bit.ly/4h7rrD3

Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction. www.nature.com/articles/s41... 1/

obesity installs an epigenetic memory that persists even after weight loss this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time

early autumn @newlimitbio.bsky.social: - 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system - +2779 TF sets tested in T cells - +51 sets that reverse phenotypic age in T cells - 5 → 7 functional assays for hepatocyte age - 0 → 80% efficiency LNP-mRNA delivery bit.ly/4g0NKJV

late summer @newlimit - world's largest partial reprogramming screen (again) - 3x'd speed of sequencing turn-around - 5x'd reprog factor library size - built our first integrated reprog corpus for model training - team += 3 blog.newlimit.com/p/july-augus...