An amazing talk from Dr. Kejia Wu in David Bakers lab at the @uwproteindesign at this year’s HD therapeutics conference in Palm Springs about her amazing designed proteins that bind intrinsically disordered peptides, including poly glutamine, which she’s working to tune to be selective for long Q’s!

Please see a collective response from an esteemed group of leaders in the dementia field to the NYT article and book “doctored” by Charles Piller. www.nytimes.com/2025/01/24/o...

TDP-43 proteinopathy also provokes transcriptomic changes consistent with TDP-43 loss of function. The latest side project from Randall Eck in my group: pubmed.ncbi.nlm.nih.gov/39810199/

Here's the latest work from my group! We built a C. elegans model of human TMEM106b proteinopathy by expressing the human gene in neurons. TMEM106b is a new kid on the block in terms of aggregating proteins. Long story short, it can driven neurodegeneration. pubmed.ncbi.nlm.nih.gov/36056242/

Love science and Seattle? Come be my colleague! We are recruiting a physician scientist to join the Seattle VA GRECC with a joint appointment at University of Washington. Apply here: apply.interfolio.com/155179. Please share widely - this is an open rank search at Assistant/ Associate/ Full levels