Odysseas Vavourakis
@odyv.bsky.social
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Generative Antibody Design at Oxford | ovavourakis.github.io | 🇬🇧🇩🇪🇬🇷(🇪🇸) he/him
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Odysseas Vavourakis
Fabian Spoendlin
7 months ago
Predicting protein conformational flexibility remains a major challenge in structural biology. While we can now accurately model static protein structures, understanding their dynamics is still difficult, largely due to a lack of suitable training data.
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It’s an exciting time in protein design! 🧬✨ But much of the therapeutic potential—especially for antibodies—remains untapped. Why? 🤔 Antibodies seem like ideal candidates for design! 💉 Here’s a quick thread summarising our new review paper on the state of antibody structure prediction. 👇 1/
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Challenges and compromises: Predicting unbound antibody structures with deep learning
Therapeutic antibodies are manufactured, stored and administered in the free state; this makes understanding the unbound form key to designing and imp…
https://www.sciencedirect.com/science/article/pii/S0959440X25000016?via%3Dihub
9 months ago
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