I saw the tears and sweat. Congratulation 🥳 @hbkgenomics.bsky.social

We've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments. 🌐 afesm.foldseek.com Read more about the work in the skeetorial 🦋 bsky.app/profile/mart... or our preprint 📄 www.biorxiv.org/content/10.1...

Today we present the poster about AFESM - the preprint opened today. It focuses on biome specific clusters, novel domain and novel combinations of domains from the 820 millions of existing protein structures #RECOMB2025

AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵 🌐 afesm.foldseek.com 📄 www.biorxiv.org/content/10.1...

Come visit us at RECOMB next year! Seoul is particularly beautiful in spring and RECOMB will have a Microbiome satellite meeting for the first time.