I grew up inspired by Attenborough's infectious enthusiasm for nature. Here my dad Colin has a cameo as Sir David narrates his work tracking swan migrations. It's a glimpse into the Pennycuick household of the 1990s, when Attenborough's Life series were required viewing! Wishing a very happy 100th.

If you have a business idea in oncology do check this out, it's a fantastic programme. Applications open now www.cancertechaccelerator.co.uk

AlphaMissense promises powerful AI for pathogenic variant identification. Is it clinically useful? Smart validation approach here against known signatures ascopubs.org/doi/10.1200/... Found with researchbriefing.com

Could we “see” intratumoral CD4 cells in vivo with PET? That’s the promise of this novel tracer. Very cool if it works www.science.org/doi/10.1126/... Found with researchbriefing.com

Night shifts increase lung cancer risk - and there's more to it than smoking. Very interesting BioBank analysis here academic.oup.com/sleep/advanc.... Found with researchbriefing.com

Immunotherapy tox is not always bad; can lead to better outcomes. More data on this in the post-CRT NSCLC setting bmcpulmmed.biomedcentral.com/articles/10.... Found with researchbriefing.com

This is a compelling vision of how AI agents will improve our treatment decisions in future www.nature.com/articles/s43.... Impressive progress but still a way from the clinic. Found with researchbriefing.com

I’ve always struggled with dermatology. Never good at identifying skin problems. Now AI can do it for us, and better www.nature.com/articles/s41... - need this in EPIC ASAP! Found with researchbriefing.com

First line ipi nivo for mNSCLC. 19% still responding at 6y. We don’t use this combo but I’m sure there are some patients who would benefit, if we could target them better www.esmoopen.com/article/S205... Found with researchbriefing.com

Cancers are complex. This study shows moving from simple biomarkers to more complex models can improve outcomes www.nature.com/articles/s41... Found with researchbriefing.com

Patients with COPD do better on immunotherapy www.nature.com/articles/s41... Found with researchbriefing.com

In genomics we tend to think in 1D sequences. Great study shows we need think in 3D www.nature.com/articles/s41... Found with researchbriefing.com

How old you look is a better predictor of outcome than how old you are. Another smart AI application shows prognostic value of FaceAge predictor in cancer patients buff.ly/e275kVV Found with researchbriefing.com

Spatial profiling of precancerous lung lesions identifies TIM3 as a potential interception target www.sciencedirect.com/science/arti.... Fantastic study. Found with researchbriefing.com

Can we improve immunotherapy responses by depleting regulatory T-cells? Encouraging data in GBM www.cell.com/immunity/ful... Found with researchbriefing.com

Can we predict patient outcomes by… asking them? Longitudinal analysis of PRO data suggests we can aacrjournals.org/clincancerre... Found with researchbriefing.com

Love this use of AI. Reviewed >600k oncology patient messages to find their main care issues. Great to focus future improvements jamanetwork.com/journals/jam... Found with researchbriefing.com

Clonal haematopoeisis; important in ageing and now associated with worse outcomes when infiltrating tumours. More great work from the TRACERx team www.nejm.org/doi/10.1056/... Found with researchbriefing.com

In scRNAseq how do you find tumour cells? This approach makes sense to me, using CNA profiles inferred from the transcriptome academic.oup.com/bib/article/... Found with researchbriefing.com

Antibiotics can affect immunotherapy efficacy via the microbiome. Should be used with caution. Helpful and detailed guide: ascopubs.org/doi/10.1200/... Found with researchbriefing.com

Adding RT to peri-op chemoIO improves MPR but not OS/PFS www.jto.org/article/S155... Found with researchbriefing.com

MetaGP - medical foundation model improves diagnostic performance of doctors buff.ly/WzRk39a Found with researchbriefing.com

This got me thinking about neoadjuvant trial design. Phase II neoadj EGFR inhibitor declared a success due to high conversion rate to resectability in unresectable stage III disease www.nature.com/articles/s41... (1/2)

Exosomes are definitely interesting for early cancer detection. AI-powered exosome detection using microfluidics seems like a smart approach buff.ly/rKqTrXu Found with researchbriefing.com

Can LLMs design proteins now? Enzymes designed with natural language prompts... incredible... buff.ly/nSvYH9Z Found with researchbriefing.com

People at germline risk of autoimmune diseases also at risk of ICI tox. Makes sense - could lead to better personalisation in future buff.ly/qj0KnOh Found with researchbriefing.com

Could protein translation defects lead to more immunogenic cancers? Could we exploit this vulnerability? Study of key translation proteins suggests so buff.ly/C6PKdF4 Found with researchbriefing.com

Here's a good question - if AI is so good at radiology interpretation, can we reduce the radiation dose? Study suggests you can, and AI copes fine with reduced quality buff.ly/GkzyUN5 Found with researchbriefing.com

DCIS recurrence is not the same as DCIS progression. Fascinating evolutionary study with important implications breast-cancer-research.biomedcentral.com/articles/10.... Found with researchbriefing.com

Serum VEGF-A as a biomarker for bevacizumab? Intriguing data www.nature.com/articles/s41... Found with researchbriefing.com

Why do some never smokers get lung cancer? Some important genetic risks identified here onlinelibrary.wiley.com/doi/10.1002/... Found with researchbriefing.com

This is great. Are radiologists really better with AI assistants? This study used “Sham AI” models as controls. Smart approach! pubs.rsna.org/doi/10.1148/... Found with researchbriefing.com

Remarkable accuracy of this AI model for lung cancer CTs. Trained and assessed on public CTs though, I wonder how it would perform on real data buff.ly/fKN53bc Found with researchbriefing.com

Understanding cancer evolution needs longitudinal data. Great to see novel tools emerge as molecular profiling becomes more sophisticated www.biorxiv.org/content/10.1... Found with researchbriefing.com

Interesting analysis of a large cohort of lung adenocarcinomas (>1000) with deep WGS and some multi-omics. Complex picture with interesting phenotypic relationships www.biorxiv.org/content/10.1... Found with researchbriefing.com

ecDNA increasingly relevant in multiple cancers. Brilliantly detailed dissection of MYC ecDNA role in pancreatic cancer here www.nature.com/articles/s41... Found with researchbriefing.com

This is the low hanging fruit for AI in oncology. Make the lives of doctors and patients easier. Seems simple but potentially huge ascopubs.org/doi/10.1200/... Found with researchbriefing.com

AI promises to improve lung cancer screening - but by how much exactly? Systematic review compares AI vs regression methods. Definitely improvement but with work to do buff.ly/qafgsbT Found with researchbriefing.com

We are always cautious of pemetrexed in renal impairment - are we being too cautious? Interesting data buff.ly/bDzXDzC Found with researchbriefing.com

Lung cancer interception trial using Sulforaphane. Lots of questions about the endpoints here but very exciting work - therapeutic prevention strategies are critical buff.ly/XDt5PtE Found with researchbriefing.com

Copy number evolution - critical in cancer and much less well understood than mutations. Interesting study mapping this process in CRC after APC loss buff.ly/4xJn0B1 Found with researchbriefing.com

Trastuzumab rezetecan. Good to see more options coming through for HER2+ NSCLC buff.ly/3Xk6lK5 Found with researchbriefing.com

Which patients shed ctDNA? Good breakdown here buff.ly/iZzOU52 - essentially more aggressive disease = more ctDNA though lots of variation. Found with researchbriefing.com

Large cohort of young onset lung cancers from China highlights ERBB2 and ALK as important. Valuable data on this challenging population buff.ly/4bibJDr Found with researchbriefing.com

Immunotherapy is new standard of care for small cell lung cancer. Real-world data suggests improvement in intracranial disease control as well as systemic https://buff.ly/3ERQA6S Found with researchbriefing.com

Is VTE in lung cancer more prevalent than we think? Should we screen? Is D-dimer useful in cancer patients with modified thresholds? Thought-provoking data https://buff.ly/41hbDaA Found with researchbriefing.com

Drug resistance tracked at extraordinary molecular resolution. Brilliant paper illustrates how complex cancers are and the challenges facing cancer vaccines https://buff.ly/414qswQ Found with researchbriefing.com

This is just brilliant. New tool dissects immune profiles from WGS. Gives novel insights into >90k (!) tumours, highlights circulating immune changes https://buff.ly/41y6Hzz Found with researchbriefing.com

So many studies on ICI response prediction. Meta analysis of cytokines highlights IL6 and IL10 https://buff.ly/3X9FKPV Found with researchbriefing.com

“Radiopathomics”: multimodal AI on radiology+path appears to outperform unimodal in early lung cancer relapse prediction https://buff.ly/4hLk98U Found with researchbriefing.com