Which hLife cover captivated you the most in 2025? It's time to pick your favorite! 🗳️ Vote now: mp.weixin.qq.com/s/nHC_gRi81r...

Twenty years of Th17: A dialogue on immunological innovation and translation Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

From outbreak to breakthrough: Scientific and technological advances in control and cure HIV/AIDS Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Genetics of protein structures Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Cooperation and innovation: An interview with Minister Ibrokhim Y. Abdurakhmonov and Professor Jinghua Cao #InnoConf24 sciencedirect.com/science/arti...

Development of targeted protein editing technique in living mammalian cells by peptide-fused PNGase Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The 2nd hLife Youth Forum was successfully held in Beijing, China

Dual frameworks for durable antibodies against SARS-CoV-2: Immune trajectories and viral fitness constraints Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

ACE2-using coronaviruses: A global concern Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Jiahai Lu has reviewed the global and Guangdong epidemic status of Chikungunya fever and its influencing factors, proposing mosquito-borne disease control strategies from a One Health perspective. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Xin-Yuan Fu has discussed the 2025 Nobel Prize-winning Treg research within the broader context of STAT-regulated immune networks. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Congratulations! The Volume 3, Issue 10 has been released! sciencedirect.com/journal/hlif...

The research group of Professor Chibuike Ibe has highlighted the global neglect of antifungal resistance research and urged for increased funding, better diagnostics and affordable therapies. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Jiyong Liu and Renjie Jiao have identified a gut-derived PGRP-SC-regulated innate immune memory in Drosophila, which is achieved through the H3K9me3-mediated epigenetic repression of PGRP-SC. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Ningning Liu has found that multiple factors could aid in early identification of postoperative infections, warranting further study. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Linhuan Wu and Juncai Ma have developed the chikungunya virus database (CHIKVdb, nmdc.cn/gcpathogen/c...), integrating global sequences and analysis tools to enhance CHIKV outbreak preparedness. Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.09.001

Congratulations! The Volume 3, Issue 9 has been released! sciencedirect.com/journal/hlif...

At the 778th Xiangshan Science Conference, participating experts systematically distilled “Ten Scientific Questions on Regional Immunity in the Pulmonary and Respiratory Mucosal Systems”. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Jie Cui has summarized that human endogenous retroviruses (HERVs) show a dual role—both as “triggers” for pathology and as “keys” to therapeutic strategies—underscoring the complex biology of aging. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Antonio Carlos Campos de Carvalho has summarized that Brazil has developed a model enabling the manufacture of and access to advanced therapy medicinal products in low- and middle-income countries. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Congratulations! The Volume 3, Issue 8 has been released! sciencedirect.com/journal/hlif...

Nobel Laureate Professor Jules A Hoffmann and his colleagues have delved into the fascinating world of innate immunity, using fruit flies as a model organism. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Prophylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.06.006

The research group of Professor Jie Feng has revealed that RmpA is a latent central regulator of HvKp, orchestrating metabolic pathways and phenotypic traits that are essential for virulence. Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.06.005

The research group of Professor Yu Vincent Fu has systematically elaborated on the innovative breakthroughs and clinical prospects of AI-powered Raman spectroscopy for pathogen identification and phenotypic detection. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Guangwen Lu has summarized the structure, function, and antiviral targeting strategies of the rabies virus glycoprotein (G), emphasizing recent structural insights into its conformational dynamics. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Guanglin He, Renkuan Tang and Chao Li have summarised recent advances in human genome completeness and diversity, urging population-specific efforts, and ethics for precision medicine. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Jun Wang has outlined the currently unknown territories in microbiology that would benefit the most from artificial intelligence. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Ning-Ning Liu has discussed the global threat of invasive fungal infections, introduced the WHO’s FPPL, and examined the current challenges and new strategies in diagnosis and treatment. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Addressing COVID-19 vaccination hesitancy through community engagement and integration with primary health care services in Wakiso District, Uganda Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Allen P. Liu and Jiahe Li have highlighted the recent work by Yichuan Xiao, Chenli Liu, et al. on engineered bacteria for cancer immunotherapy and discuss its future. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Yu Sun and Congchao Cheng have examined three linked paradigms of AI—tool, mirror, and assistant—to show their strengths and limits, emphasizing key aspects of human ingenuity. Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.05.009

The research group of Professor Di Dong has reviewed the challenges faced by AI in medical diagnosis applications from the perspectives of responsibility allocation, data ethics, and explainability. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Xiangwei Li and Tianlang Tong have investigated twelve distinct DNAm aging algorithms' mortality links while evaluating and comparing their predictive abilities for mortality. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Chengyuan Wang and Vadim Molodtsov have summarized transcription-translation coupling and factor-dependent termination in bacteria and archaea, emphasizing mechanistic differences. @ChengyuanWang3 Read more on hLife👇📷https://doi.org/10.1016/j.hlife.2025.05.007

The research groups of Professors Xinwei Han and Ran Xu have summarized microbiota–innate immunity crosstalk in health and cancer, highlighting immune recognition and polarization during tumor progression. Read more on hLife👇📷https://doi.org/10.1016/j.hlife.2025.05.008

Congratulations! The Volume 3, Issue 6 has been released! www.sciencedirect.com/journal/hlif...

The research groups of Professor Minggui Wang has proposed new perspectives and insights into the formation, transmission, detection, and treatment strategies of both CR-hvKp and hv-CRKp strains. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Wenming Wu, Yanshan Liang, and Xudong Liu has summarize the latest experimental models used to study pancreatic cancer cachexia and discuss potential treatment strategies. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Ming He has reviewed the Cell study by Professor Guang-Hui Liu's group, proposing that future exercise-related health benefits could be achieved through targeted pharmacological interventions. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Rational design of human CD26 receptor for a strong neutralizing ability against MjHKU4r-CoV-1 and MERS-CoV Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Jianping Xie has provided comprehensive insights into the intricate interplay between ISG15/ISGylation and copper-related pathways. Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.05.003

Mucosal adenovirus vaccine Ad5-XBB.1.5 boosting elicits nasal IgA and transiently prevents JN.1 wave infection for less than 6 months in real-world settings Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.05.001

Selection and engineering of broad-spectrum antiviral affibody peptide against SARS-CoV-2 variants Read more on hLife👇👇👇https://doi.org/10.1016/j.hlife.2025.04.010

The research group of Professor Qiang Li has identified "brain damage" accumulation as ASD's core pathological mechanism and proposes combined damage-control and self-repair strategies for intervention. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

Congratulations! The Volume 3, Issue 6 has been released! sciencedirect.com/journal/hlif...

Congratulations! The Volume 3, Issue 5 has been released! sciencedirect.com/journal/hlif...

Systemic profiling of immune responses in healthy adults vaccinated with an RBD-targeting COVID-19 mRNA vaccine Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research group of Professor Jiuxin Qu has analyzed a series of K. pneumoniae strains from a patient with persistent infection, revealing their intra-host population dynamics from a quasispecies perspective. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...

The research groups of Professors Hui Yang, Yunlong Cao, Xiaotian Tan, et al. have developed a portable diagnostic system that evaluates an individual’s antibody protection using just one microliter of fingertip blood. Read more on hLife👇👇👇 doi.org/10.1016/j.hl...