Carla Abreu (@carlamcabreu.bsky.social)

Can #cilia grow without #dynein-2 mediated retrograde #IFT?👀 Yes, they can! Removing the ciliary gate lets trapped IFT components escape via diffusion & ciliary #EVs, driving axoneme elongation. 👉 doi.org/10.1101/2025... 🧬 Work led with @dantas-lab.bsky.social, in collaboration with Peterman lab.

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Removal of the Ciliary Gate Allows Axoneme Extension in the Absence of Retrograde IFT The transition zone (TZ) is a selective barrier that maintains ciliary compartmentalization by controlling protein entry and exit. Cilia assembly requires the crossing of this barrier by intraflagella... https://doi.org/10.1101/2025.10.21.683645

18 days ago