Peptide-based vaccines are redefining precision immunology, offering safety, specificity,scalable manufacturing. This review explores how bioinformatics-driven epitope design, nanoparticles,& next-gen adjuvants are fighting viral threats 🚀🦠 journals.sagepub.com/doi/full/10....

Ticks strike twice 🐜🐜 Fatal Babesia microti/Borrelia burgdorferi coinfection presenting as acute liver failure and shock. Read full case @ journals.sagepub.com/doi/full/10....

🦠 Rare but severe: necrotizing gingival & sinus infection due to Trichoderma longibrachiatum in an allo-HSCT recipient. Cure achieved with aggressive surgery 🔪 + combination antifungals 💊, including consolidation with rezafungin. journals.sagepub.com/doi/full/10....

Febrile neutropenia still drives heavy carbapenem use due to MDR Gram-negatives. In a cohort of 553 FN episodes, an ML risk model + prior colonisation data could cut meropenem use by ~30% and IEAT from 23% to 9%, supporting personalised EAT. journals.sagepub.com/doi/full/10....

Chronic pulmonary aspergillosis can complicate pulmonary echinococcosis via residual lung cavities. In this review (41 studies, 72 CPA cases), diagnosis relied on radiology/histology, combined surgical–medical therapy led to uniformly favorable outcomes journals.sagepub.com/doi/full/10....

⚠️ Rising MDR in cUTIs demands new options. Plazomicin shows strong in-vitro activity, synergy with key agents, and favorable outcomes in trials—yet real-world evidence from LMICs is urgently needed 📉📊. journals.sagepub.com/doi/full/10....

Imidazolopiperazines (KAF156/ganaplacide) show potent activity across blood, liver, and gametocyte stages of Plasmodium 🦟💊—a promising path forward as antimalarial resistance rises. journals.sagepub.com/doi/full/10....

🧬 Unusual infection: M. luteus, normally a skin commensal, triggered prosthetic valve endocarditis in an immunocompetent woman. 8 weeks of IV vancomycin led to full recovery. journals.sagepub.com/doi/full/10....

📊 New study from Teso, Uganda: Among 1009 TB patients, overall treatment success was 91.9%. Females had higher success, while age >49 and HIV infection lowered success. Early screening, preventive therapy, and peer support are key to improving outcomes. journals.sagepub.com/doi/full/10....

Antipseudomonal beta lactams yielded outcomes similar to cefazolin/oxacillin in this study of of MSSA bacteremia.However there were more complicated infections in the SOC arm.These data may inform antibiotic choices when broad coverage is needed. journals.sagepub.com/doi/full/10....

Check out highlights from the 2025 Group B Strep in Pregnancy & Babies Conference: new data spanning antimicrobial stewardship, epidemiology, diagnostics, prevention policies, virulence profiling, and next-gen sequencing for neonatal GBS. journals.sagepub.com/doi/full/10....

AI-driven models are showing clear promise in improving HIV/TB detection and management in Nigeria, where immunosuppression drives disproportionate TB risk. Strengthening technical capacity will be essential for translating this potential into practice. journals.sagepub.com/doi/full/10....

Data from 89 patients suggest that follow-up FDG-PET/CT can guide decisions in focal infections but is most informative when bacteremia is gram-positive or clinical status deteriorates. Findings support targeted rather than routine use. 🔍🦠📊 journals.sagepub.com/doi/full/10....

Recurrent UTIs remain a major burden, and new guidance is steering care toward non-antibiotic prevention—behavioural measures, topical oestrogen, methenamine hippurate, and intravesical HA/CS 💡💊💧 Read this review for more 📘✨ journals.sagepub.com/doi/full/10....

Antibiotics disrupt gut/airway microbiomes across ages 🦠, amplifying both targeted and background resistance genes 🧬. Recovery remains especially poor in children 👶 journals.sagepub.com/doi/full/10....

A multistep UTI-focused stewardship initiative reduced unnecessary treatment of asymptomatic presentations by 12% & improved adherence to UTI management guidelines. journals.sagepub.com/doi/full/10....

Novel entomo-virological tools, such as honey-baited traps preserving mosquito-expectorated RNA, are reshaping arbovirus monitoring. Integrating these with genomic surveillance can bridge field ecology and molecular epidemiology. 🔬🦟https://journals.sagepub.com/doi/full/10.1177/20499361251391261

P. aeruginosa is the archetype of adaptive resistance—porins close, pumps activate, enzymes evolve. New β-lactam/β-lactamase inhibitor combos and cefiderocol offer treatment options. journals.sagepub.com/doi/full/10....

📈 Retrospective time-series study (2014–2019, Mysuru, India): Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia. Findings suggest climate–infection interplay with implications for AMR trends. journals.sagepub.com/doi/full/10....

Meta-analysis (7 studies, n=1685): Cefazolin vs. ASPs for MSSA endocarditis — similar efficacy, lower 30-day mortality (OR 0.49, 95% CI 0.29–0.83), and fewer adverse events. Supports cefazolin as a viable alternative journals.sagepub.com/doi/full/10....

🚨study from Bolivia: A novel PCR platform—Orange G3 TBC—shows comparable accuracy to GeneXpert Ultra for TB diagnosis (sensitivity = 90%, specificity = 97%). Its biosafe, low-resource–friendly design could expand TB testing access in endemic settings. journals.sagepub.com/doi/full/10....

Excited to see everyone at #IDWeek2025! Catch the @TAInfDis team sharing insights across these great sessions.

A systematic review (2003–2023) shows live attenuated (LAIV) and inactivated (IIV) influenza vaccines protect children/adolescents equally well (~50% VE). Post-2017 LAIV strain updates restored H1N1 protection and improved efficacy vs influenza B. journals.sagepub.com/doi/full/10....

In a survey of 128 HIV care workers, negative attitudes toward people who use drugs were strongly linked to lower acceptance of harm reduction practices. Acceptance varied by site, race, and experience—pointing to structural and training gaps. journals.sagepub.com/doi/full/10....

Dolutegravir/lamivudine improved quality of life, treatment acceptability, and symptom burden in PLWH over 6 months (French multicenter study, n=260). Gains appeared by month 1 and persisted. Monitoring discontinuations—especially among women—remains key. journals.sagepub.com/doi/full/10....

Systematic review/meta-analysis (2013–2024, n=23,319): In febrile neutropenia after chemotherapy, bloodstream infections were 59% Gram-negative, 39.7% Gram-positive, and 2.5% fungal. journals.sagepub.com/doi/full/10....

The Clade IIb #mpox 🌍 outbreak exposed major gaps in evidence for antivirals 💊, vaccine equity 💉, and surveillance. This review maps the path toward targeted, evidence-based treatments and prevention✨ journals.sagepub.com/doi/full/10....

ED study in Japan: Relaxation of COVID-19 IPC practices led to a surge in virus-related exacerbations of COPD (7.7%→52.5%) & asthma (39.7%→66.7%). Reinforcing viral prevention is key in chronic airway disease care. journals.sagepub.com/doi/full/10....

📊 HIV from injection drug use is climbing (2016–2022). PrEP uptake in PWID remains critically low. Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education. journals.sagepub.com/doi/full/10....

Hospital clinician training transformed care for PWUD w/ severe infections. Post-training: 95% applied harm reduction (vs 55%), 69% discussed safer use (vs 38%). journals.sagepub.com/doi/full/10....

East Jerusalem hospital study (2019–2023): CRE in 20.6% of Enterobacterales isolates; blaNDM dominated (82%), blaOXA-48 (13%). Prevalence rising, Klebsiella most common. journals.sagepub.com/doi/full/10....

Despite free HIV care & PrEP in Peru, HIV incidence among youth remains high (13% at age 18; 25% in trans youth <18). Restricting PrEP to 18+ misses a critical window. Peru must expand PrEP to 15–17-year-olds. journals.sagepub.com/doi/full/10....

In CNS neuroimmunological disease, anti-CD20/S1PRM therapies blunt humoral responses even after 4th SARS-CoV-2 vaccine dose or breakthrough infection. Encouragingly, no evidence of intermediate-term neuroinflammation or neural injury post-COVID-19 journals.sagepub.com/doi/full/10....

Rare case: concurrent Mycobacterium avium & M. kansasii infection in a patient w/ MDS & germline GATA2, on cobimetinib. Suggests profound susceptibility to NTM & therapeutic challenges in this setting. journals.sagepub.com/doi/10.1177/...

Real-world fascioliasis data (174 pts, TriNetX 2021–24): common comorbidities, GI symptoms, biliary complications in ~10%, 90-day mortality <6%. Triclabendazole reported in just 6%—access or reporting gap? Prospective studies needed journals.sagepub.com/doi/full/10....

UTIs drive huge antimicrobial use worldwide. This editorial highlights innovations—PCR, AMR surveillance, PROMs—to guide sustainable, patient-centred therapy. journals.sagepub.com/doi/full/10....

🧪 Meta-analysis of 5,399 patients: RA patients show TNF-α levels comparable to those in sepsis. ⚠️ Anti-TNF therapy works in RA but not sepsis → TNF-α unlikely to be central in sepsis biology. journals.sagepub.com/doi/full/10....

Chikungunya: a strong contender for Disease X. ✔ Key mutations drive rapid spread ✔ Debilitating chronic disease + neonatal risk ✔ Vaccine inequity, no treatment ✔ Climate & travel accelerate reach Global vigilance is critical. journals.sagepub.com/doi/full/10....

🇻🇳 Cross-sectional study of 876 pregnant women in Hanoi: GBS colonization prevalence 19.5%. Independent risk factors: higher education & yellow vaginal discharge. Predominant serotypes: III, V, VI. journals.sagepub.com/doi/full/10....

💉 Bloodstream infections from carbapenemase-producing Enterobacterales in acute leukemia carry high mortality (~61%). In a Peruvian cohort, use of ceftazidime–avibactam cut 30-day mortality risk by 70% vs. other therapies (aHR 0.29, 95% CI 0.09–0.92). journals.sagepub.com/doi/full/10....

💉 “Tranq” (xylazine) + fentanyl → rising overdoses, devastating necrotic wounds, & systemic infections. This vignette shows why new harm reduction tools like drug-checking are urgently needed. journals.sagepub.com/doi/full/10....

In a 6-year retrospective, propensity-matched analysis of 111 patients with invasive candidiasis, anidulafungin and caspofungin showed comparable efficacy (global response 63.3% vs 56.3%, p=0.49) and no difference in 90-day mortality. journals.sagepub.com/doi/full/10....

🚨Yellow fever is resurging in the Americas. As of April 2025, over 200 human cases and 85 deaths have been reported—CFR ~40%. The virus is moving beyond its traditional Amazonian stronghold. This isn’t just an outbreak—it's a warning.🧵 journals.sagepub.com/doi/full/10....

First reported case of Mycoplasma hominis prosthetic valve endocarditis + endophthalmitis post-renal transplant. ✅ Diagnosed by plasma cfDNA mNGS after culture-negative workup ✅ Managed with surgery + doxy/levo journals.sagepub.com/doi/full/10....

PVL+ Staph aureus ⚡️ causes severe skin infections. In Calabar 🇳🇬, 12.5% of S. aureus isolates were PVL+, tied to recurrent infections & daycare work 🏫. journals.sagepub.com/doi/full/10....

🦠 Biofilms fuel #AMR & chronic infections, needing 100–1000x more antibiotics to clear. Phages can disrupt biofilms & fight resistant bacteria but face bacterial defenses. Phage-antimicrobial combos may enhance antibiofilm strategies. journals.sagepub.com/doi/full/10....

UTIs aren’t just “simple infections.” They bring anxiety, frustration, & recurrent misery for many. AMR, delayed dx, & clinician focus only on physical symptoms worsen the burden. We need better dialogue & AMR education for patients. journals.sagepub.com/doi/full/10....

In NE India’s Manipur, HCV sero-reactivity quadruples in PLHIV who inject drugs. 40% have genotype 6; phylogenetics link strains to SE Asia. journals.sagepub.com/doi/full/10....

🩺💉 Rising IE in PWID, but Syringe service program use is patchy due to rural gaps & relapse fears. 🏥 Discharge planning = chance to connect PWID to harm reduction for safer futures. journals.sagepub.com/doi/full/10....

Group B Strep (GBS) isn't just a neonatal issue—it’s linked to preterm birth, PPROM, UTI, endometritis & maternal sepsis too. 🦠 We need better prevention beyond intrapartum antibiotics. Maternal GBS vaccines may be the path forward. journals.sagepub.com/doi/full/10....