New systematic review & meta-analysis in SSA HCWs shows moderate AMR knowledge (65%) and attitudes (69%), but weaker practices (54%), with a clear knowledge–practice gap—most evident among doctors (knowledge 65%, practice 43%). journals.sagepub.com/doi/full/10....

TB treatment is evolving—but persistence remains a major barrier. New evidence shows macrophage metabolism and redox state shape intracellular drug tolerance in Mtb. Host-directed strategies may enhance antibiotic efficacy and help shorten therapy ⏳ journals.sagepub.com/doi/full/10....

Case report: a young patient with years of “chronic lung disease” ultimately diagnosed with aggressive HTLV-1 driven lymphoma-fatal within weeks. Early biopsy + T-cell panel (CD4+CD25+ with CD7 loss) should trigger HTLV-1 testing, regardless of geography. journals.sagepub.com/doi/full/10....

CKD and UTIs form a vicious cycle: kidney dysfunction increases infection risk ; while recurrent UTIs accelerate renal decline. Breaking this loop demands early CKD detection, antimicrobial stewardship & non-antibiotic prevention strategies. journals.sagepub.com/doi/full/10....

Neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are valuable, readily available markers for gauging severity in community-acquired pneumonia 🦠📊 journals.sagepub.com/doi/10.1177/...

CKD and UTIs form a dangerous feedback loop 🔁: impaired immunity and structural changes drive recurrent, often MDR infections, which in turn hasten kidney decline. Prevention, early detection, and stewardship are central to breaking the cycle journals.sagepub.com/doi/full/10....

Prospective study (Ukraine/Moldova/Spain, n=287): mfloDx™ MDR-TB assay achieved Se 100% / Sp 98.7% for INH+RIF resistance vs culture DST. Caveat: 35% inconclusive results. Potential role as rapid screening tool. journals.sagepub.com/doi/full/10....

Does EV-D68 amplify TB immunopathology? Case series suggests coinfection may worsen lung inflammation, with clinical response seen after corticosteroid escalation. A reminder to consider viral triggers in atypical TB courses. journals.sagepub.com/doi/10.1177/...

Arboviruses don’t act in isolation 🦟 Chikungunya and Zika spread where structural vulnerabilities persist—limited surveillance, inequity, and inadequate sanitation. Future resilience depends on integrating social and biological surveillance systems 🧬. journals.sagepub.com/doi/10.1177/...

Diagnosing invasive mold infections 🧫 in immunocompromised patients remains difficult.NGS 🧬 offers noninvasive, actionable insights-identifying missed infections and guiding therapy in over half of cases. journals.sagepub.com/doi/10.1177/...

Malaria 🦟 + soil-transmitted helminths 🪱 often co-infect young children in Nigeria, driving early red cell changes 🩸 before overt anaemia. Host factors esp haemoglobin genotype 🧬matter more than parasite load. journals.sagepub.com/doi/10.1177/...

New meta-analysis 📊: HBV escape mutations are common in LMICs 🧬 Immune escape ~56% 💊 Resistance highest with 3TC/LdT journals.sagepub.com/doi/full/10....

Case report: in HIV patient with recurrent Cryptocccal meningitis 🧠 despite virologic suppression, re-induction + isavuconazole led to immune recovery, viral control, and no further CM episodes over 6 months journals.sagepub.com/doi/full/10....

Chronic pulmonary aspergillosis + pulmonary embolism = a challenging duo 🫁🦠🩸Mechanisms may include inflammation + endothelial damage 🧬Management is tricky—anticoagulation vs hemoptysis risk ⚖️https://journals.sagepub.com/doi/full/10.1177/20499361261431900

P: Mild COVID-19 pneumonia 🦠 I: Clarithromycin 800 mg/day 💊 C: Standard of care O: No significant change in time to 50% symptom improvement, but ↓ fatigue and ↓ inflammatory cytokines. Signals of immunomodulation worth further study. 🔬 journals.sagepub.com/doi/full/10....

Contingency management isn’t just for abstinence.A harm-reduction clinic for people who use drugs used incentives to encourage risk assessment, testing, clinic engagement to reduce HIV and infection risk.Early results show engagement among patients. journals.sagepub.com/doi/full/10....

In a survey of women in 🇿🇦 younger women& those engaged in transactional sex were more likely to intend to use PrEP, while condom users were less likely. #HIVPrevention #PrEP journals.sagepub.com/doi/full/10....

Strongyloides hyperinfection can occur without eosinophilia—even with CD4 >500 and undetectable HIV viral load. Early diagnosis is lifesaving ⚠️ journals.sagepub.com/doi/full/10....

Invasive pulmonary aspergillosis remains a lethal threat in immunocompromised and post-COVID patients 🦠 Advances in PCR, lateral flow assays, and immuno-PET/MRI are reshaping diagnosis, but rising azole resistance demands susceptibility testing journals.sagepub.com/doi/full/10....

In this systematic review (29 studies), mNGS outperformed culture for spinal infections with broader pathogen detection,higher sensitivity,faster turnaround⏱️ Challenges remain: cost & distinguishing colonization from infection. journals.sagepub.com/doi/full/10....

Peptide-based vaccines are redefining precision immunology, offering safety, specificity,scalable manufacturing. This review explores how bioinformatics-driven epitope design, nanoparticles,& next-gen adjuvants are fighting viral threats 🚀🦠 journals.sagepub.com/doi/full/10....

Ticks strike twice 🐜🐜 Fatal Babesia microti/Borrelia burgdorferi coinfection presenting as acute liver failure and shock. Read full case @ journals.sagepub.com/doi/full/10....

🦠 Rare but severe: necrotizing gingival & sinus infection due to Trichoderma longibrachiatum in an allo-HSCT recipient. Cure achieved with aggressive surgery 🔪 + combination antifungals 💊, including consolidation with rezafungin. journals.sagepub.com/doi/full/10....

Febrile neutropenia still drives heavy carbapenem use due to MDR Gram-negatives. In a cohort of 553 FN episodes, an ML risk model + prior colonisation data could cut meropenem use by ~30% and IEAT from 23% to 9%, supporting personalised EAT. journals.sagepub.com/doi/full/10....

Chronic pulmonary aspergillosis can complicate pulmonary echinococcosis via residual lung cavities. In this review (41 studies, 72 CPA cases), diagnosis relied on radiology/histology, combined surgical–medical therapy led to uniformly favorable outcomes journals.sagepub.com/doi/full/10....

⚠️ Rising MDR in cUTIs demands new options. Plazomicin shows strong in-vitro activity, synergy with key agents, and favorable outcomes in trials—yet real-world evidence from LMICs is urgently needed 📉📊. journals.sagepub.com/doi/full/10....

Imidazolopiperazines (KAF156/ganaplacide) show potent activity across blood, liver, and gametocyte stages of Plasmodium 🦟💊—a promising path forward as antimalarial resistance rises. journals.sagepub.com/doi/full/10....

🧬 Unusual infection: M. luteus, normally a skin commensal, triggered prosthetic valve endocarditis in an immunocompetent woman. 8 weeks of IV vancomycin led to full recovery. journals.sagepub.com/doi/full/10....

📊 New study from Teso, Uganda: Among 1009 TB patients, overall treatment success was 91.9%. Females had higher success, while age >49 and HIV infection lowered success. Early screening, preventive therapy, and peer support are key to improving outcomes. journals.sagepub.com/doi/full/10....

Antipseudomonal beta lactams yielded outcomes similar to cefazolin/oxacillin in this study of of MSSA bacteremia.However there were more complicated infections in the SOC arm.These data may inform antibiotic choices when broad coverage is needed. journals.sagepub.com/doi/full/10....

Check out highlights from the 2025 Group B Strep in Pregnancy & Babies Conference: new data spanning antimicrobial stewardship, epidemiology, diagnostics, prevention policies, virulence profiling, and next-gen sequencing for neonatal GBS. journals.sagepub.com/doi/full/10....

AI-driven models are showing clear promise in improving HIV/TB detection and management in Nigeria, where immunosuppression drives disproportionate TB risk. Strengthening technical capacity will be essential for translating this potential into practice. journals.sagepub.com/doi/full/10....

Data from 89 patients suggest that follow-up FDG-PET/CT can guide decisions in focal infections but is most informative when bacteremia is gram-positive or clinical status deteriorates. Findings support targeted rather than routine use. 🔍🦠📊 journals.sagepub.com/doi/full/10....

Recurrent UTIs remain a major burden, and new guidance is steering care toward non-antibiotic prevention—behavioural measures, topical oestrogen, methenamine hippurate, and intravesical HA/CS 💡💊💧 Read this review for more 📘✨ journals.sagepub.com/doi/full/10....

Antibiotics disrupt gut/airway microbiomes across ages 🦠, amplifying both targeted and background resistance genes 🧬. Recovery remains especially poor in children 👶 journals.sagepub.com/doi/full/10....

A multistep UTI-focused stewardship initiative reduced unnecessary treatment of asymptomatic presentations by 12% & improved adherence to UTI management guidelines. journals.sagepub.com/doi/full/10....

Novel entomo-virological tools, such as honey-baited traps preserving mosquito-expectorated RNA, are reshaping arbovirus monitoring. Integrating these with genomic surveillance can bridge field ecology and molecular epidemiology. 🔬🦟https://journals.sagepub.com/doi/full/10.1177/20499361251391261

P. aeruginosa is the archetype of adaptive resistance—porins close, pumps activate, enzymes evolve. New β-lactam/β-lactamase inhibitor combos and cefiderocol offer treatment options. journals.sagepub.com/doi/full/10....

📈 Retrospective time-series study (2014–2019, Mysuru, India): Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia. Findings suggest climate–infection interplay with implications for AMR trends. journals.sagepub.com/doi/full/10....

Meta-analysis (7 studies, n=1685): Cefazolin vs. ASPs for MSSA endocarditis — similar efficacy, lower 30-day mortality (OR 0.49, 95% CI 0.29–0.83), and fewer adverse events. Supports cefazolin as a viable alternative journals.sagepub.com/doi/full/10....

🚨study from Bolivia: A novel PCR platform—Orange G3 TBC—shows comparable accuracy to GeneXpert Ultra for TB diagnosis (sensitivity = 90%, specificity = 97%). Its biosafe, low-resource–friendly design could expand TB testing access in endemic settings. journals.sagepub.com/doi/full/10....

Excited to see everyone at #IDWeek2025! Catch the @TAInfDis team sharing insights across these great sessions.

A systematic review (2003–2023) shows live attenuated (LAIV) and inactivated (IIV) influenza vaccines protect children/adolescents equally well (~50% VE). Post-2017 LAIV strain updates restored H1N1 protection and improved efficacy vs influenza B. journals.sagepub.com/doi/full/10....

In a survey of 128 HIV care workers, negative attitudes toward people who use drugs were strongly linked to lower acceptance of harm reduction practices. Acceptance varied by site, race, and experience—pointing to structural and training gaps. journals.sagepub.com/doi/full/10....

Dolutegravir/lamivudine improved quality of life, treatment acceptability, and symptom burden in PLWH over 6 months (French multicenter study, n=260). Gains appeared by month 1 and persisted. Monitoring discontinuations—especially among women—remains key. journals.sagepub.com/doi/full/10....

Systematic review/meta-analysis (2013–2024, n=23,319): In febrile neutropenia after chemotherapy, bloodstream infections were 59% Gram-negative, 39.7% Gram-positive, and 2.5% fungal. journals.sagepub.com/doi/full/10....

The Clade IIb #mpox 🌍 outbreak exposed major gaps in evidence for antivirals 💊, vaccine equity 💉, and surveillance. This review maps the path toward targeted, evidence-based treatments and prevention✨ journals.sagepub.com/doi/full/10....

ED study in Japan: Relaxation of COVID-19 IPC practices led to a surge in virus-related exacerbations of COPD (7.7%→52.5%) & asthma (39.7%→66.7%). Reinforcing viral prevention is key in chronic airway disease care. journals.sagepub.com/doi/full/10....

📊 HIV from injection drug use is climbing (2016–2022). PrEP uptake in PWID remains critically low. Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education. journals.sagepub.com/doi/full/10....

Hospital clinician training transformed care for PWUD w/ severe infections. Post-training: 95% applied harm reduction (vs 55%), 69% discussed safer use (vs 38%). journals.sagepub.com/doi/full/10....