Another new preprint from our lab! This one details our efforts to produce new PqsE inhibitors and methods for assessing their potential to induce a conformational shift and weaken the interaction with RhlR. Haven't gotten there yet, but our methods are getting more sophisticated 😉

We had a wonderful time at #ACSFall2025! Bilalay, Ada, and Maggie all presented posters and everyone learned new things/met new people. Can’t wait for the next one! @acs.org

New preprint from our lab! Here we identified FDA-approved molecules that inhibit the enzyme activity of our favorite quorum sensing protein, PqsE. Work was led by 3 undergraduate and 1 MS student and in part comes from a collaboration with our Sep Lab neighbors! 🦠🧪

@lizneeley.bsky.social is publishing a weekly newsletter to track the ongoing attacks in science and higher ed. If you want to keep abreast without drowning in the news, I recommend it: buttondown.com/liminalcreat...

Small-molecule protein chaperones may have more wide-ranging activity than we thought, and that's good news:

Congrats to Bonnie!

Ok so Twitter doesn't really help with these things anymore. Anyone have grant rejection stories to share that'll make me feel better? I got this one on my third and final attempt for a particular grant. And it came in at 10 pm. On New Year's Eve. 🙃 #newPI #grantrejection

And with that, we have a new Survivor winner! And a totally deserving winner at that. #Survivor47

Not loving that my first post on this app has a typo in it. Did we ever get that “edit post” button? 🤦🏻‍♀️

Very excited to share our lab's first preprint! This work was lead by 2 undergrad and one masters student: Bilalay Tchadi, Jesse Derringer, and Anna Detweiler. Here we describe the ability of our favorite enzyme, PqsE, to fine-tune RhlR's transcription factor activity in a promoter-specific manner: