New paper at @chemcomm.rsc.org with @lsalassa.bsky.social and I14 at @diamondlightsource.bsky.social X-ray spectromicroscopy shows that conjugating flavins to PtIV prodrugs improve greatly activation efficiency, even at much lower irradiation dose! @dipcehu.bsky.social doi.org/10.1039/D5CC...

Will be opening soon a position for a PhD student at the DIPC. The student would use X-ray imaging or spectroscopic techniques to probe metallodrugs during biological dynamic processes Contact me ([email protected]) for more information, attaching a CV and a brief statement of interest.

A gold nanoparticle may start out as a neatly engineered sphere with a protective coating. But the moment it encounters blood or tissue fluid, proteins, fats, and sugars begin to stick to it.  https://mappingignorance.org/2025/08/07/x-rays-reveal-the-true-identity-of-nanoparticles-in-medicine/

The difficulty lies in the fact that once nanoparticles enter the human body, they rarely remain in the form in which they were designed. 

Nanoparticles are not just tiny tools; they are dynamic players in a complex biological game. Thanks to advanced X‑ray methods, we are finally learning the rules.

This article breaks down the findings, exploring why size matters, how spheroids serve as testing grounds, and what lies ahead for nanoparticle research. https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/

By testing gold nanoparticles, using sophisticated imaging techniques, the study reveals critical insights into designing nanoparticles for effective cancer therapy.  https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/

This article breaks down the findings, exploring why size matters, how spheroids serve as testing grounds, and what lies ahead for nanoparticle research. https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/

A new review examines how nanoparticle size influences their ability to penetrate 3D tumour spheroids—simplified models that mimic real tumours. 

Very proud of this in #SMALL. Working with Marvin Skiba from the Parak group at #CHyN in Hamburg and P62 beamline at #DESY Using Anomalous SAXS to study separately each of the individual components of metal NPs and the protein corona around! @dipcehu.bsky.social doi.org/10.1002/smll...

Good to see this out in #AdvancedDrugDeliveryReviews. Great work with the Parak group from #CHyN in Hamburg and P06 beamline at #DESY Have a look to see how different imaging techniques compare for the study of nanoparticle penetration in spheroids! @dipcehu.bsky.social doi.org/10.1016/j.ad...

X-ray fluorescence imaging, a pivotal tool in modern biological research. By @dipcehu.bsky.social  https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/

In a study, researchers investigated the use of biodegradable polyelectrolyte capsules as carriers for selenium compounds. https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/

Final one of 2024 at @jsynchrotronrad.iucr.org Need a free 3D printed cryo-transporter of silicon nitride membranes? Tested at @esrf.fr @diamondlightsource.bsky.social #desy Done with Antonio Dominguez-Alfaro around some #papasconchocos and #cruzcampo @dipcehu.bsky.social doi.org/10.1107/S160...

Good to see this out in #ChemicalScience, it was coming for a while. Great work with Fernando Lopez-Gallego and Javier Santiago from #CICbiomaGUNE at the #esrf Have a look to see how we use X-rays to study the exhaustion of biocatalysts! @dipcehu.bsky.social pubs.rsc.org/en/content/a...